Multiple-Network Alterations in Major Depressive Disorder With Gastrointestinal Symptoms at Rest Revealed by Global Functional Connectivity Analysis.

ABSTRACT:

Objective

Gastrointestinal (GI) symptoms are prominent in major depressive disorder (MDD) and bring patients lots of complaints and troubles. We aimed to explore whether there were some distinctive brain image alterations in MDD with GI symptoms, which could be used to distinguish MDD with GI symptoms from those without GI symptoms and healthy controls (HCs).

Methods

A total of 35 outpatients with GI symptoms, 17 outpatients without GI symptoms, and 28 HCs were recruited. All the participants were scanned by a resting-state functional magnetic resonance imaging. Imaging data were analyzed with the global functional connectivity (GFC) and support vector machine methods.

Results

MDD with GI symptoms showed decreased GFC in the left superior medial prefrontal cortex (MPF

SUBMITTER: Yan M 

PROVIDER: S-EPMC9263397 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature