Functional Connectivity Dynamics Altered of the Resting Brain in Subjective Cognitive Decline.

ABSTRACT:

Background

Subjective cognitive decline (SCD) appears in the preclinical stage of the Alzheimer's disease continuum. In this stage, dynamic features are more sensitive than static features to reflect early subtle changes in functional brain connectivity. Therefore, we studied local and extended dynamic connectivity of the resting brain of people with SCD to determine their intrinsic brain changes.

Methods

We enrolled cognitively normal older adults from the communities and divided them into SCD and normal control (NC) groups. We used mean dynamic amplitude of low-frequency fluctuation (mdALFF) to evaluate region of interest (ROI)-wise local dynamic connectivity of resting-state functional MRI. The dynamic functional connectivity (dFC) between ROIs was tested by whole-brain-b

SUBMITTER: Wei YC 

PROVIDER: S-EPMC9263398 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature