Urinary Trace Elements Are Biomarkers for Early Detection of Acute Kidney Injury.

ABSTRACT:

Introduction

Acute kidney injury (AKI) is common in hospitalized patients and associated with poor outcomes. Current methods for identifying AKI (rise in serum creatinine [sCr] or fall in urine output [UO]) are inadequate and delay detection. Early detection of AKI with easily measurable biomarkers might improve outcomes by facilitating early implementation of AKI care pathways.

Methods

From a porcine model of AKI, we identified trace elements (TEs) in urine that were associated with subsequent development of AKI. We tested these putative biomarkers in 2 observational cohort studies of patients at high risk of AKI: 151 patients undergoing cardiac surgery and 150 patients admitted to a general adult intensive care unit (ICU).

Results

In adults admitted to the ICU, urin

SUBMITTER: Gardner DS 

PROVIDER: S-EPMC9263416 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature