Increased LDL receptor by SREBP2 or SREBP2-induced lncRNA LDLR-AS promotes triglyceride accumulation in fish.
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ABSTRACT:
SUBMITTER: Cao X
PROVIDER: S-EPMC9263516 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
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Increased LDL receptor by SREBP2 or SREBP2-induced lncRNA LDLR-AS promotes triglyceride accumulation in fish.
Cao Xiufei X Fang Wei W Li Xueshan X Wang Xiuneng X Mai Kangsen K Ai Qinghui Q
iScience 20220626 7
LDLR, as the uptake receptor of low-density lipoprotein, plays a crucial role in lipid metabolism. However, the detailed mechanism by which LDLR affects hepatic triglyceride (TG) accumulation has rarely been reported. Here, we found that knockdown of LDLR effectively mitigated PA-induced TG accumulation. Further analysis revealed that the expression of LDLR was controlled by SREBP2 directly and indirectly. On one hand, transcription factor SREBP2 activated the transcription of LDLR directly. On ...[more]
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