Continuous flow synthesis of azobenzenes via Baeyer-Mills reaction.

ABSTRACT: Azobenzene, as one of the most prominent molecular switches, is featured in many applications ranging from photopharmacology to information or energy storage. In order to easily and reproducibly synthesize non-symmetric substituted azobenzenes in an efficient way, especially on a large scale, the commonly used Baeyer-Mills coupling reaction was adopted to a continuous flow setup. The versatility was demonstrated with a scope of 20 substances and the scalability of this method exemplified by the synthesis of >70 g of an azobenzene derivative applied in molecular solar thermal storage (MOST) systems.

SUBMITTER: Griwatz JH 

PROVIDER: S-EPMC9263553 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature