False Positive Findings of [¹⁸F]PSMA-1007 PET/CT in Patients After Radical Prostatectomy with Undetectable Serum PSA Levels.

ABSTRACT:

Background

PET-CT using prostate-specific membrane antigen (PSMA)-targeting radiopharmaceuticals labeled with ⁶⁸Ga or ¹⁸F has emerged as the most sensitive staging tool in prostate cancer (PC). Nonetheless, the occurrence of false positive (FP) findings presents a major concern of this approach. In this prospective study, we investigated the frequency and pattern of false-positive findings of [¹⁸F]PSMA-1007 PET/CT in patients after radical prostatectomy with undetectable serum PSA levels. Any discrete non-physiological accumulation of [¹⁸F]PSMA-1007 in this population is by definition FP.

Methods

Seventeen men after radical prostatectomy, whose serum PSA levels were <0.05 ng/mL at 2-24 months after surgery were prospectively recrui

SUBMITTER: Orevi M 

PROVIDER: S-EPMC9263625 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature