UVB irradiation differential regulate miRNAs expression in skin photoaging.

ABSTRACT:

Background

UVB irradiation can cause acute damage such as sunburn, or photoaging and melanoma, all of which are major health threats.

Objective

This study was designed to investigate the mechanism of skin photoaging induced by UVB radiation in mice through the analysis of the differential expression of miRNAs.

Methods

A UVB irradiation photoaging model was constructed. HE and Masson special stains were used to examine the modifications in the epidermis and dermis of mice. The miRNA expression profiles of the mouse skin model exposed to UVB radiation and the normal skin of mice were analyzed using miRNA-sequence analysis. GO and Pathway analysis were employed for the prediction of miRNA targets.

Results

A total of 23 miRNAs were evaluated for significantly diffe

SUBMITTER: Fang Y 

PROVIDER: S-EPMC9263642 | biostudies-literature | 2022 Jul-Aug

REPOSITORIES: biostudies-literature