Beneficial effect of capsaicin via TRPV4/EDH signals on mesenteric arterioles of normal and colitis mice.

ABSTRACT:

Introduction

Although capsaicin has long been used as food additive and medication worldwide, its actions on gastrointestinal tract as its most delivery pathway have not been well addressed.

Objectives

In the present study, we aimed to study GI actions of capsaicin on mesenteric arterioles in normal and colitis mice and to elucidate the underlying mechanisms.

Methods

Vasorelaxation of human submucosal arterioles and the mesenteric arterioles from wide-type (WT) mice, TRPV1^-/- and TRPV4^-/- (KO) mice were measured. The expression and function of TRPV channels in endothelial cells were examined by q-PCR, immunostaining, Ca²⁺ imaging and membrane potential measurements.

Results

Capsaicin dose-dependently induced vasorelaxation of hu

SUBMITTER: Zhang L 

PROVIDER: S-EPMC9263647 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature