NFIL3 deficiency alleviates EAE through regulating different immune cell subsets.

ABSTRACT:

Introduction

The transcription factor NFIL3 exerts comprehensive effects on the immune system. Previous studies revealed that NFIL3 is related to the function and development of different immune cell subsets. Experimental autoimmune encephalomyelitis (EAE) is mediated by immune cells which results in inflammatory demyelination in the central nervous system (CNS). However, how NFIL3 affects EAE has not been thoroughly studied.

Objectives

The current study aimed to investigate how NFIL3 affects EAE, especially the changes of T cells and dendritic cells as well as the crosstalk between them.

Methods

We used NFIL3^-/- mice and C57BL/6J mice (wildtype) to establish MOG35-55-induced EAE. The clinical scores were recorded daily. The immune cells within and outside

SUBMITTER: Chen Z 

PROVIDER: S-EPMC9263648 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature