Transcription factor Meis1 act as a new regulator of ischemic arrhythmias in mice.

ABSTRACT:

Introduction

The principal voltage-gated Na⁺ channel, Na_V1.5 governs heart excitability and conduction. Na_V1.5 dysregulation is responsible for ventricular arrhythmias and subsequent sudden cardiac death (SCD) in post-infarct hearts. The transcription factor Meis1 performs a significant role in determining differentiation fate and regenerative capability of cardiomyocytes. However, the functions of Meis1 in ischemic arrhythmias following myocardial infarction (MI) are still largely undefined.

Objectives

Here we aimed to study whether Meis1 could act as a key regulator to mediate cardiac Na⁺ channel and its underlying mechanisms.

Methods

Heart-specific Meis1 overexpression was established by AAV9 virus injection in C57BL/6 mi

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9263651 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature