Harnessing microbial iron chelators to develop innovative therapeutic agents.

ABSTRACT:

Background

Bacterial infections involving multidrug-resistant Gram-negative bacteria have become critically involved in the current antibiotic crisis. This, together with the bacterial evolution ability, prioritizes the discovery of new antibiotics. Research on microbial iron acquisition pathways and metabolites, particularly siderophores, has highlighted hopeful aspects for the design of advanced antimicrobial approaches. Moreover, exploiting siderophores machinery to treat diseases associated with iron overload and cancer is of additional interest for the therapeutic arena.

Aim of review

This review highlights and provides a renewed perspective on the evolutionary path of siderophores, from primordial siderophores to new iron chelating agents, stimulating the field to buil

SUBMITTER: Ribeiro M 

PROVIDER: S-EPMC9263657 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature