The multiomics landscape of serum exosomes during the development of sepsis.

ABSTRACT:

Introduction

Sepsis is an infection-induced severe inflammatory disorder leading to multiple organ dysfunction. It remains a highly lethal condition for which early diagnosis and therapy achieve unsatisfactory results. Circulating exosomes containing biomarkers and mediators of sepsis have recently received attention, but the progress has been far from optimal.

Objectives

The present study focuses on the profiles of molecular dynamics in serum exosomes and explores the potential molecular mechanisms on serum exosomes during the process of sepsis.

Methods

We used high-performance liquid chromatography-tandem mass spectrometry and RNA-seq to detect the dynamic profiles of exosome proteins and RNAs (including mRNAs, lncRNAs and miRNAs) in serum exosomes from 3 healthy in

SUBMITTER: Li L 

PROVIDER: S-EPMC9263672 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature