Optimal Hormone Replacement Therapy in Hypothyroidism - A Model Predictive Control Approach.

ABSTRACT: In this paper, we address the problem of optimal thyroid hormone replacement strategy development for hypothyroid patients. This is challenging for the following reasons. First, it is difficult to determine the correct dosage leading to normalized serum thyroid hormone concentrations of a patient. Second, it remains unclear whether a levothyroxine L-T₄) monotherapy or a liothyronine/levothyroxine (L-T₃/L-T₄) combined therapy is more suitable to treat hypothyroidism. Third, the optimal intake frequency of L-T₃/L-T₄ is unclear. We address these issues by extending a mathematical model of the pituitary-thyroid feedback loop to be able to consider an oral intake of L<

SUBMITTER: Wolff TM 

PROVIDER: S-EPMC9263720 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature