New indication of Chuankezhi injection for steroid-resistant focal segmental glomerulosclerosis and its mechanism of action.

ABSTRACT:

Background

Chuankezhi (CKZ) injection is a traditional Chinese medicine (TCM) injection extracted from Chinese herbs Epimedium sagittatum (Yin Yang Huo) and Morinda officinalis (Bai Ji Tian). Studies have shown that CKZ has a positive effect on improving diabetic nephropathy and regulating immune function. Focal segmental glomerulosclerosis (FSGS) is a kind of refractory nephropathy, which has been confirmed as closely associated with immunity. Whether CKZ is effective against FSGS and how it works warrant further study. This study aimed to verify the efficacy of CKZ in rats with steroid-resistant (SR) FSGS and explore its mechanism of action.

Methods

We established an SR FSGS model in male Sprague Dawley (SD) rats by injecting adriamycin into the tail vein. Ba

SUBMITTER: Liang R 

PROVIDER: S-EPMC9263774 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature