Identification of novel drug targets for the risk and prognosis of COVID-19.

ABSTRACT:

Background

Since the epidemic continues, there is a pressing need to improve our understanding of coronavirus disease 2019 (COVID-19). Mendelian randomization (MR) studies provide us with a method to explore the causality between circulating proteins and COVID-19 susceptibility and severity. We aim to find new perspectives on the pathological mechanism of the disease and possible drug targets for treatment based on this study.

Methods

We conducted a phenome-wide MR study to prioritize circulating proteins causally associated with COVID-19 susceptibility, which was defined as "patients tested positive for COVID-19 vs. population controls", and severity, which was defined as "patients hospitalized with COVID-19 vs. population controls". And we repeated the analys

SUBMITTER: Gan YH 

PROVIDER: S-EPMC9263786 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature