CIRMI-a new term for a concept worthy of further exploration: a narrative review.

ABSTRACT:

Background and objective

Critical illness-related corticosteroid insufficiency (CIRCI) describes hypothalamic-pituitary-axis impairment during critical illness associated with three major pathophysiological events; dysregulation of the hypothalamic-pituitary-axis, altered cortisol metabolism, and tissue corticosteroid resistance. Similar changes are evident with regard to mineralocorticoid dysfunction in critical illness. Hyperreninemic hypoaldosteronism describes a sub-population of critically ill patients with an impaired adrenal aldosterone response to increased levels of renin. In the light of the recent demonstration of significant mortality improvements associated with adjunctive glucocorticoid treatment in combination with fludrocortisone in septic shock, and the suggestion

SUBMITTER: Nethathe GD 

PROVIDER: S-EPMC9263790 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature