The Diversity and Spatiotemporally Evolutionary Dynamic of Atypical Porcine Pestivirus in China.

ABSTRACT: The presence of congenital tremor (CT) type A-II in newborn piglets, caused by atypical porcine pestivirus (APPV), has been a focus since 2016. However, the source, evolutionary history, and transmission pattern of APPV in China remain poorly understood. In this study, we undertook phylogenetic analyses based on available complete E2 gene sequences along with 98 newly sequenced E2 genes between 2016 and 2020 in China within the context of global genetic diversity. The phylogenies revealed four distinct lineages of APPV, and interestingly, all lineages could be detected in China with the greatest diversity. Bayesian phylogenetic analyses showed that the E2 gene evolves at a mean rate of 1.22 × 10^-3 (8.54 × 10^-4-1.60 × 10^-3) substitutions/site/year. The most

SUBMITTER: Ma H 

PROVIDER: S-EPMC9263985 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature