Prognostic significance of PD-L1 expression and CD8⁺ TILs density for disease-free survival in surgically resected lung squamous cell carcinoma: a retrospective study.

ABSTRACT:

Background

This study sought to depict the genomic landscape of patients with surgically resected lung squamous cell carcinoma (LUSC) and its relationship with clinical outcome indicators.

Methods

We retrospectively collected the clinical data of 180 patients from the electronic medical records and applied targeted sequencing and immunohistochemistry (IHC) to depict the genomic landscape, including the tumor mutation burden (TMB), programmed cell death-ligand 1 (PD-L1), and cluster of differentiation CD8⁺ tumor-infiltrating lymphocytes (CD8⁺ TILs). And comparative analysis and survival analysis of these parameters were conducted to find prognostic factors for clinical outcome.

Results

PD-L1+ tumor cells were observed in 75 (41.7%) of the patients

SUBMITTER: Cheng X 

PROVIDER: S-EPMC9264043 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature