Serial evaluation of segmental esophageal reconstruction using a polyurethane scaffold in a pig model.

ABSTRACT:

Background

Many esophageal pathologies are clinically treated by resection and reconstruction of the esophagus. Surgical esophagectomy remains a morbid procedure and despite minimally invasive advances, has changed little in decades. Novel approaches to esophageal segmental resection and reconstruction are an unmet need.

Methods

Circumferential thoracic esophageal transection was performed in both male and female pigs and the defects reconstructed using 5 or 10 cm polyurethane (PU) tubular grafts and stented. A subset were treated with stent only. Animals were survived to 14, 30, 60, and 399 days. Tissues were evaluated histologically, and via non-invasive serial endoscopy and contrast swallowing studies in long-term animals.

Results

Luminal patency was achieved in al

SUBMITTER: Sarrafian TL 

PROVIDER: S-EPMC9264045 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature