Association between brain structural network efficiency at term-equivalent age and early development of cerebral palsy in very preterm infants.

ABSTRACT: Very preterm infants (born at less than 32 weeks gestational age) are at high risk for serious motor impairments, including cerebral palsy (CP). The brain network changes that antecede the early development of CP in infants are not well characterized, and a better understanding may suggest new strategies for risk-stratification at term, which could lead to earlier access to therapies. Graph theoretical methods applied to diffusion MRI-derived brain connectomes may help quantify the organization and information transfer capacity of the preterm brain with greater nuance than overt structural or regional microstructural changes. Our aim was to shed light on the pathophysiology of early CP development, before the occurrence of early intervention therapies and other environmental confounders, t

SUBMITTER: Kline JE 

PROVIDER: S-EPMC9264481 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature