External Validation of a Breath-Based Prediction Model for Malignant Pleural Mesothelioma.

ABSTRACT: During the past decade, volatile organic compounds (VOCs) in exhaled breath have emerged as promising biomarkers for malignant pleural mesothelioma (MPM). However, as these biomarkers lack external validation, no breath test for MPM has been implemented in clinical practice. To address this issue, we performed the first external validation of a VOC-based prediction model for MPM. The external validation cohort was prospectively recruited, consisting of 47 MPM patients and 76 asbestos-exposed (AEx) controls. The predictive performance of the previously developed model was assessed by determining the degree of agreement between the predicted and actual outcome of the participants (patient/control). Additionally, to optimise the performance, the model was updated by refitting it to the valida

SUBMITTER: Janssens E 

PROVIDER: S-EPMC9264774 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature