Ontology highlight
ABSTRACT:
SUBMITTER: Margarido AS
PROVIDER: S-EPMC9264851 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Margarido Andreia S AS Uceda-Castro Rebeca R Hahn Kerstin K de Bruijn Roebi R Kester Lennart L Hofland Ingrid I Lohuis Jeroen J Seinstra Danielle D Broeks Annegien A Jonkers Jos J Broekman Marike L D MLD Wesseling Pieter P Vennin Claire C Vizoso Miguel M van Rheenen Jacco J
Cancers 20220625 13
(1) Background: an increasing number of breast cancer patients develop lethal brain metastases (BM). The complete removal of these tumors by surgery becomes complicated when cells infiltrate into the brain parenchyma. However, little is known about the nature of these invading cells in breast cancer brain metastasis (BCBM). (2) Methods: we use intravital microscopy through a cranial window to study the behavior of invading cells in a mouse model of BCBM. (3) Results: we demonstrate that BCBM cel ...[more]