Prostate Cancer Survivors Present Long-Term, Residual Systemic Immune Alterations.

ABSTRACT:

Background

The development of cancer and anti-tumor therapies can lead to systemic immune alterations but little is known about how long immune dysfunction persists in cancer survivors.

Methods

We followed changes in the cellular immune parameters of prostate cancer patients with good prognostic criteria treated with low dose rate brachytherapy before and up to 3 years after the initiation of therapy.

Results

Patients before therapy had a reduced CD4+ T cell pool and increased regulatory T cell fraction and these alterations persisted or got amplified during the 36-month follow-up. A significant decrease in the total NK cell number and a redistribution of the circulating NK cells in favor of a less functional anergic subpopulation was seen in patients before therapy b

SUBMITTER: Balazs K 

PROVIDER: S-EPMC9264868 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature