Mesothelioma Mouse Models with Mixed Genomic States of Chromosome and Microsatellite Instability.

ABSTRACT: Malignant mesothelioma (MMe) is a rare malignancy originating from the linings of the pleural, peritoneal and pericardial cavities. The best-defined risk factor is exposure to carcinogenic mineral fibers (e.g., asbestos). Genomic studies have revealed that the most frequent genetic lesions in human MMe are mutations in tumor suppressor genes. Several genetically engineered mouse models have been generated by introducing the same genetic lesions found in human MMe. However, most of these models require specialized breeding facilities and long-term exposure of mice to asbestos for MMe development. Thus, an alternative model with high tumor penetrance without asbestos is urgently needed. We characterized an orthotopic model using MMe cells derived from Cdkn2a^+/-;Nf2^+/-

SUBMITTER: Song Y 

PROVIDER: S-EPMC9264972 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature