Survival Outcomes and Prognostic Factors in Glioblastoma.

ABSTRACT:

Background

IDH-wildtype glioblastoma is the most common malignant primary brain tumour in adults. As there is limited information on prognostic factors outside of clinical trials; thus, we conducted a retrospective study to characterise the glioblastoma population at our centre.

Methods

Demographic, tumour molecular profiles, treatment, and survival data were collated for patients diagnosed with glioblastoma at our centre between July 2011 and December 2015. We used multivariate proportional hazard model associations with survival.

Results

490 patients were included; 60% had debulking surgery and 40% biopsy only. Subsequently, 56% had standard chemoradiotherapy, 25% had non-standard chemo/radio-therapy, and 19% had no further treatment. Overall survival was 9.2 months

SUBMITTER: Brown NF 

PROVIDER: S-EPMC9265012 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature