Circulating and Tumor-Infiltrating Immune Checkpoint-Expressing CD8⁺ Treg/T Cell Subsets and Their Associations with Disease-Free Survival in Colorectal Cancer Patients.

ABSTRACT: T cells in the tumor microenvironment (TME) have diverse roles in anti-tumor immunity, including orchestration of immune responses and anti-tumor cytotoxic attack. However, different T cell subsets may have opposing roles in tumor progression, especially in inflammation-related cancers such as colorectal cancer (CRC). In this study, we phenotypically characterized CD3⁺CD4^- (CD8⁺) T cells in colorectal tumor tissues (TT), normal colon tissues (NT) and in circulation of CRC patients. We investigated the expression levels of key immune checkpoints (ICs) and Treg-related markers in CD8⁺ T cells. Importantly, we investigated associations between different tumor-infiltrating CD8⁺ T cell subpopulations and disease-free survival (DFS) in CRC p

SUBMITTER: Alsalman A 

PROVIDER: S-EPMC9265020 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature