Antitumoral Effects of Tricyclic Antidepressants: Beyond Neuropathic Pain Treatment.

ABSTRACT: Growing evidence shows that nerves play an active role in cancer development and progression by altering crucial molecular pathways and cell functions. Conversely, the use of neurotropic drugs, such as tricyclic antidepressants (TCAs), may modulate these molecular signals with a therapeutic purpose based on a direct antitumoral effect and beyond the TCA use to treat neuropathic pain in oncology patients. In this review, we discuss the TCAs' safety and their central effects against neuropathic pain in cancer, and the antitumoral effects of TCAs in in vitro and preclinical studies, as well as in the clinical setting. The current evidence points out that TCAs are safe and beneficial to treat neuropathic pain associated with cancer and chemotherapy, and they block different molecular pathways

SUBMITTER: Asensi-Canto A 

PROVIDER: S-EPMC9265090 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature