A Multimodal Biomarker Predicts Dissemination of Bronchial Carcinoid.

ABSTRACT:

Background

Curatively treated bronchial carcinoid tumors have a relatively low metastatic potential. Gradation into typical (TC) and atypical carcinoid (AC) is limited in terms of prognostic value, resulting in yearly follow-up of all patients. We examined the additional prognostic value of novel immunohistochemical (IHC) markers to current gradation of carcinoids.

Methods

A retrospective single-institution cohort study was performed on 171 patients with pathologically diagnosed bronchial carcinoid (median follow-up: 66 months). The risk of developing distant metastases based on histopathological characteristics (Ki-67, p16, Rb, OTP, CD44, and tumor diameter) was evaluated using multivariate regression analysis and the Kaplan-Meier method.

Results

Of 171 patients, sev

SUBMITTER: Reuling EMBP 

PROVIDER: S-EPMC9265109 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature