Tissue-Based Proteomic Profiling in Patients with Hyperplasia and Endometrial Cancer.

ABSTRACT: Uterine cancers are among the most prevalent gynecological malignancies, and endometrial cancer (EC) is the most common in this group. This study used tissue-based proteomic profiling analysis in patients with endometrial cancer and hyperplasia, and control patients. Conventional 2D gel electrophoresis, followed by a mass spectrometry approach with bioinformatics, including a network pathway analysis pipeline, was used to identify differentially expressed proteins and associated metabolic pathways between the study groups. Thirty-six patients (twelve with endometrial cancer, twelve with hyperplasia, and twelve controls) were enrolled in this study. The mean age of the participants was 46-75 years. Eighty-seven proteins were significantly differentially expressed between the study groups, o

SUBMITTER: Akkour K 

PROVIDER: S-EPMC9265283 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature