The E3 Ubiquitin Ligase Peli1 Deficiency Promotes Atherosclerosis Progression.

ABSTRACT:

Background

Atherosclerosis is a chronic inflammatory vascular disease and the main cause of death and morbidity. Emerging evidence suggests that ubiquitination plays an important role in the pathogenesis of atherosclerosis including control of vascular inflammation, vascular smooth muscle cell (VSMC) function and atherosclerotic plaque stability. Peli1 a type of E3 ubiquitin ligase has emerged as a critical regulator of innate and adaptive immunity, however, its role in atherosclerosis remains to be elucidated.

Methods

Apoe^-/- mice and Peli1-deficient Apoe^-/- Peli1^-/- mice were subject to high cholesterol diet. Post sacrifice, serum was collected, and atherosclerotic plaque size and parameters of atherosclerotic plaque stability were evaluate

SUBMITTER: Burger F 

PROVIDER: S-EPMC9265341 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature