Maternal Vitamin D Deficiency in Mice Increases White Adipose Tissue Inflammation in Offspring.

ABSTRACT: Vitamin D is acknowledged to play an important biological and metabolic role in adipose tissue, which is also the main storage site for this vitamin. Its anti-inflammatory effect in adipocytes and adipose tissue has notably been highlighted in adult mice. This vitamin is also crucial during fetal development since maternal vitamin D deficiency is suspected to program future metabolic disorders. Based on these observations, the aim of this study was to evaluate the consequences of maternal vitamin D deficiency (VDD) on white adipose tissue inflammation in adult offspring fed with normal or obesogenic diet (high-fat diet). White adipose tissue morphology, RNA and miRNA expression profiles, and signaling pathways were studied in adult males and females. In males, a HF diet coupled with matern

SUBMITTER: Haroun N 

PROVIDER: S-EPMC9265671 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature