The Route of the Malignant Plasma Cell in Its Survival Niche: Exploring "Multiple Myelomas".

ABSTRACT: Growing evidence points to multiple myeloma (MM) and its stromal microenvironment using several mechanisms to subvert effective immune and anti-tumor responses. Recent advances have uncovered the tumor-stromal cell influence in regulating the immune-microenvironment and have envisioned targeting these suppressive pathways to improve therapeutic outcomes. Nevertheless, some subgroups of patients include those with particularly unfavorable prognoses. Biological stratification can be used to categorize patient-, disease- or therapy-related factors, or alternatively, these biological determinants can be included in a dynamic model that customizes a given treatment to a specific patient. Genetic heterogeneity and current knowledge enforce a systematic and comprehensive bench-to-bedside approach

SUBMITTER: Solimando AG 

PROVIDER: S-EPMC9265748 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature