IPCD: A Comprehensive Data Resource of Regulatory Proteins in Programmed Cell Death.

ABSTRACT: Programmed cell death (PCD) is an essential biological process involved in many human pathologies. According to the continuous discovery of new PCD forms, a large number of proteins have been found to regulate PCD. Notably, post-translational modifications play critical roles in PCD process and the rapid advances in proteomics have facilitated the discovery of new PCD proteins. However, an integrative resource has yet to be established for maintaining these regulatory proteins. Here, we briefly summarize the mainstream PCD forms, as well as the current progress in the development of public databases to collect, curate and annotate PCD proteins. Further, we developed a comprehensive database, with integrated annotations for programmed cell death (iPCD), which contained 1,091,014 regulatory

SUBMITTER: Tang D 

PROVIDER: S-EPMC9265749 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature