Computer-Aided Multi-Epitope Vaccine Design against Enterobacter xiangfangensis.

ABSTRACT: Antibiotic resistance is a global public health threat and is associated with high mortality due to antibiotics' inability to treat bacterial infections. Enterobacter xiangfangensis is an emerging antibiotic-resistant bacterial pathogen from the Enterobacter genus and has the ability to acquire resistance to multiple antibiotic classes. Currently, there is no effective vaccine against Enterobacter species. In this study, a chimeric vaccine is designed comprising different epitopes screened from E. xiangfangensis proteomes using immunoinformatic and bioinformatic approaches. In the first phase, six fully sequenced proteomes were investigated by bacterial pan-genome analysis, which revealed that the pathogen consists of 21,996 core proteins, 3785 non-redundant proteins and 18,2

SUBMITTER: Alshammari A 

PROVIDER: S-EPMC9265868 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature