CAMP Signaling in Cancer: A PKA-CREB and EPAC-Centric Approach.

ABSTRACT: Cancer is one of the most common causes of death globally. Despite extensive research and considerable advances in cancer therapy, the fundamentals of the disease remain unclear. Understanding the key signaling mechanisms that cause cancer cell malignancy may help to uncover new pharmaco-targets. Cyclic adenosine monophosphate (cAMP) regulates various biological functions, including those in malignant cells. Understanding intracellular second messenger pathways is crucial for identifying downstream proteins involved in cancer growth and development. cAMP regulates cell signaling and a variety of physiological and pathological activities. There may be an impact on gene transcription from protein kinase A (PKA) as well as its downstream effectors, such as cAMP response element-binding protei

SUBMITTER: Ahmed MB 

PROVIDER: S-EPMC9266045 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature