A multi-epitope vaccine designed against blood-stage of malaria: an immunoinformatic and structural approach.

ABSTRACT: Malaria is a complex disease caused by parasites of the genus Plasmodium and is the leading cause of morbidity and mortality worldwide. The most severe form of malaria disease is caused by Plasmodium falciparum. Thus, a combination of different approaches is needed to control malaria. Resistance to first-line drugs and insecticides, on the other hand, makes the need for an effective vaccination more urgent than ever. Because erythrocyte parasites cause the most clinical symptoms, developing a vaccination for this stage of infection might be highly beneficial. In this research, we employed various bioinformatics methods to create an efficient multi-epitope vaccine that induces antibodies against the blood stage of malaria infection. For this purpose, we selected the malaria PfGARP protein a

SUBMITTER: Atapour A 

PROVIDER: S-EPMC9266094 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature