T-Lymphocyte Interactions with the Neurovascular Unit: Implications in Intracerebral Hemorrhage.

ABSTRACT: In the pathophysiology of hemorrhagic stroke, the perturbation of the neurovascular unit (NVU), a functional group of the microvascular and brain intrinsic cellular components, is implicated in the progression of secondary injury and partially informs the ultimate patient outcome. Given the broad NVU functions in maintaining healthy brain homeostasis through its maintenance of nutrients and energy substrates, partitioning central and peripheral immune components, and expulsion of protein and metabolic waste, intracerebral hemorrhage (ICH)-induced dysregulation of the NVU directly contributes to numerous destructive processes in the post-stroke sequelae. In ICH, the damaged NVU precipitates the emergence and evolution of perihematomal edema as well as the breakdown of the blood-brain barrie

SUBMITTER: Shi SX 

PROVIDER: S-EPMC9266108 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature