Effects of Moderate Consumption of Red Wine on Hepcidin Levels in Patients with Type 2 Diabetes Mellitus.

ABSTRACT: Iron overload is often associated with type 2 diabetes (T2D), indicating that hepcidin, the master regulator of iron homeostasis, might be involved in diabetes pathogenesis. Alcohol consumption may also result in increased body iron stores. However, the moderate consumption of wine with meals might be beneficial in T2D. This effect has been mainly attributed to both the ethanol and the polyphenolic compounds in wine. Therefore, we examined the effects of red wine on hepcidin in T2D patients and non-diabetic controls. The diabetic patients (n = 18) and age- and BMI-matched apparently healthy controls (n = 13) were men, aged 40-65 years, non-smoking, with BMI < 35 kg/m². Following a 2-week alcohol-free period, both groups consumed 300 mL of red wine for 3 weeks. T

SUBMITTER: Nazlic J 

PROVIDER: S-EPMC9266169 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature