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Solo vs. Chorus: Monomers and Oligomers of Arrestin Proteins.

ABSTRACT: Three out of four subtypes of arrestin proteins expressed in mammals self-associate, each forming oligomers of a distinct kind. Monomers and oligomers have different subcellular localization and distinct biological functions. Here we summarize existing evidence regarding arrestin oligomerization and discuss specific functions of monomeric and oligomeric forms, although too few of the latter are known. The data on arrestins highlight biological importance of oligomerization of signaling proteins. Distinct modes of oligomerization might be an important contributing factor to the functional differences among highly homologous members of the arrestin protein family.

SUBMITTER: Gurevich VV

PROVIDER: S-EPMC9266314 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Solo vs. Chorus: Monomers and Oligomers of Arrestin Proteins.

Gurevich Vsevolod V VV Gurevich Eugenia V EV

International journal of molecular sciences 20220629 13

Three out of four subtypes of arrestin proteins expressed in mammals self-associate, each forming oligomers of a distinct kind. Monomers and oligomers have different subcellular localization and distinct biological functions. Here we summarize existing evidence regarding arrestin oligomerization and discuss specific functions of monomeric and oligomeric forms, although too few of the latter are known. The data on arrestins highlight biological importance of oligomerization of signaling proteins. ...[more]

PMID: 35806256

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