Protein-Protein Interaction Prediction for Targeted Protein Degradation.

ABSTRACT: Protein-protein interactions (PPIs) play a fundamental role in various biological functions; thus, detecting PPI sites is essential for understanding diseases and developing new drugs. PPI prediction is of particular relevance for the development of drugs employing targeted protein degradation, as their efficacy relies on the formation of a stable ternary complex involving two proteins. However, experimental methods to detect PPI sites are both costly and time-intensive. In recent years, machine learning-based methods have been developed as screening tools. While they are computationally more efficient than traditional docking methods and thus allow rapid execution, these tools have so far primarily been based on sequence information, and they are therefore limited in their ability to addr

SUBMITTER: Orasch O 

PROVIDER: S-EPMC9266413 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature