The Analysis of a Genome-Wide Association Study (GWAS) of Overweight and Obesity in Psoriasis.

ABSTRACT: There is evidence that the concomitance of psoriasis and obesity may originate from the interplay between multiple genetic pathways and involve gene−gene interactions. The aim of this study was to compare the genetic background related to obesity among psoriatic patients versus healthy controls by means of a Genome-Wide Association Study (GWAS). A total of 972 psoriatic patients and a total of 5878 healthy donors were enrolled in this study. DNA samples were genotyped for over 500,000 single nucleotide polymorphisms (SNPs) using Infinium CoreExome BeadChips (Illumina, San Diego, CA, USA). Statistical analysis identified eleven signals (p < 1 × 10−5) associated with BMI across the study groups and revealed a varying effect size in each sub-cohort. Seven of the alternative alleles (rs1558902

SUBMITTER: Kisielnicka A 

PROVIDER: S-EPMC9266424 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature