The Role of Microglia in the (Mal)adaptive Response to Traumatic Experience in an Animal Model of PTSD.

ABSTRACT: The present study investigates whether predator scent-stress (PSS) shifts the microglia from a quiescent to a chronically activated state and whether morphological alterations in microglial activation differ between individuals displaying resilient vs. vulnerable phenotypes. In addition, we examined the role that GC receptors play during PSS exposure in the impairment of microglial activation and thus in behavioral response. Adult male Sprague Dawley rats were exposed to PSS or sham-PSS for 15 min. Behaviors were assessed with the elevated plus-maze (EPM) and acoustic startle response (ASR) paradigms 7 days later. Localized brain expression of Iba-1 was assessed, visualized, and classified based on their morphology and stereological counted. Hydrocortisone and RU486 were administered syste

SUBMITTER: Nahum K 

PROVIDER: S-EPMC9266429 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature