Noncatalytic Domains in DNA Glycosylases.
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ABSTRACT:
SUBMITTER: Torgasheva NA
PROVIDER: S-EPMC9266487 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
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Noncatalytic Domains in DNA Glycosylases.
Torgasheva Natalia A NA Diatlova Evgeniia A EA Grin Inga R IR Endutkin Anton V AV Mechetin Grigory V GV Vokhtantsev Ivan P IP Yudkina Anna V AV Zharkov Dmitry O DO
International journal of molecular sciences 20220630 13
Many proteins consist of two or more structural domains: separate parts that have a defined structure and function. For example, in enzymes, the catalytic activity is often localized in a core fragment, while other domains or disordered parts of the same protein participate in a number of regulatory processes. This situation is often observed in many DNA glycosylases, the proteins that remove damaged nucleobases thus initiating base excision DNA repair. This review covers the present knowledge a ...[more]
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