Long-Term Changes in Axon Calibers after Injury: Observations on the Mouse Corticospinal Tract.

ABSTRACT: White matter pathology is common across a wide spectrum of neurological diseases. Characterizing this pathology is important for both a mechanistic understanding of neurological diseases as well as for the development of neuroimaging biomarkers. Although axonal calibers can vary by orders of magnitude, they are tightly regulated and related to neuronal function, and changes in axon calibers have been reported in several diseases and their models. In this study, we utilize the impact acceleration model of traumatic brain injury (IA-TBI) to assess early and late changes in the axon diameter distribution (ADD) of the mouse corticospinal tract using Airyscan and electron microscopy. We find that axon calibers follow a lognormal distribution whose parameters significantly change after injury. W

SUBMITTER: Alexandris AS 

PROVIDER: S-EPMC9266552 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature