Characteristics and risk factors of infections in patients with HBV-related acute-on-chronic liver failure: a retrospective study.

ABSTRACT:

Background

Acute-on-chronic liver failure (ACLF) is a syndrome characterized by acute decompensation, organ failures, and high short-term mortality whose main cause in China is the Hepatitis B virus (HBV). Moreover, one of the most important causes of morbidity and mortality in HBV-ACLF patients is bacterial infection. Therefore, we investigate the clinical features, risk factors, prophylaxis and management of infections in patients with HBV-ACLF.

Methods

We conducted a retrospective analysis of 539 patients with HBV-ACLF in Wuhan Tongji Hospital from October 2015 to May 2018. Differences among groups were compared with Student's t test, Mann-Whitney U test, χ² test, or Fisher exact test as appropriate. Univariate and Multivariate logistic regression analysis was

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC9266584 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature