The Atomically Precise Gold/Captopril Nanocluster Au₂₅(Capt)₁₈ Gains Anticancer Activity by Inhibiting Mitochondrial Oxidative Phosphorylation.

ABSTRACT: Atomically precise gold nanoclusters (AuNCs) are an emerging class of quantum-sized nanomaterials with well-defined molecular structures and unique biophysical properties, rendering them highly attractive for biological applications. We set out to study the impact of different ligand shells of atomically similar nanoclusters on cellular recognition and response. To understand the effects of atomically precise nanoclusters with identical composition on cells, we selected two different water-soluble gold nanoclusters protected with captopril (Capt) and glutathione (GSH): Au₂₅(Capt)₁₈ (CNC) and Au₂₅(GSH)₁₈ (GNC), respectively. We demonstrated that a change of the ligand of the cluster completely changes its biological functions. Whereas both nanoclu

SUBMITTER: Bhattacharya SR 

PROVIDER: S-EPMC9266621 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature