Mechanism of Bile Acid-Induced Programmed Cell Death and Drug Discovery against Cancer: A Review.

ABSTRACT: Bile acids are major signaling molecules that play a significant role as emulsifiers in the digestion and absorption of dietary lipids. Bile acids are amphiphilic molecules produced by the reaction of enzymes with cholesterol as a substrate, and they are the primary metabolites of cholesterol in the body. Bile acids were initially considered as tumor promoters, but many studies have deemed them to be tumor suppressors. The tumor-suppressive effect of bile acids is associated with programmed cell death. Moreover, based on this fact, several synthetic bile acid derivatives have also been used to induce programmed cell death in several types of human cancers. This review comprehensively summarizes the literature related to bile acid-induced programmed cell death, such as apoptosis, autophagy,

SUBMITTER: Jang JY 

PROVIDER: S-EPMC9266679 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature