MiR-1183 Is a Key Marker of Remodeling upon Stretch and Tachycardia in Human Myocardium.

ABSTRACT: Many cardiac insults causing atrial remodeling are linked to either stretch or tachycardia, but a comparative characterization of their effects on early remodeling events in human myocardium is lacking. Here, we applied isometric stretch or sustained tachycardia at 2.5 Hz in human atrial trabeculae for 6 h followed by microarray gene expression profiling. Among largely independent expression patterns, we found a small common fraction with the microRNA miR-1183 as the highest up-regulated transcript (up to 4-fold). Both, acute stretch and tachycardia induced down-regulation of the predicted miR-1183 target genes ADAM20 and PLA2G7. Furthermore, miR-1183 was also significantly up-regulated in chronically remodeled atrial samples from patients with persistent atrial fibrillation

SUBMITTER: Djalinac N 

PROVIDER: S-EPMC9266684 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature