Palliative Effect of Resveratrol against Nanosized Iron Oxide-Induced Oxidative Stress and Steroidogenesis-Related Genes Dysregulation in Testicular Tissue of Adult Male Rats.

ABSTRACT: The nano-sized iron oxide (Fe₂O₃-NPs) is one of the most used engineered nanomaterials worldwide. This study investigated the efficacy of natural polyphenol resveratrol (RSV) (20 mg/kg b.wt, orally once daily) to alleviate the impaired sperm quality and testicular injury resulting from Fe₂O₃-NPs exposure (3.5 or 7 mg/kg b.wt, intraperitoneally once a week) for eight weeks. Spermiograms, sexual hormonal levels, oxidative stress indicators, and lipid peroxidation biomarker were assessed. Moreover, the steroidogenesis-related genes mRNA expressions were evaluated. The results showed that RSV substantially rescued Fe₂O₃-NPs-mediated sperm defects. Additionally, the Fe₂O₃-NPs-induced depressing effects on sp

SUBMITTER: Ahmed MM 

PROVIDER: S-EPMC9266693 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature