Efficacy of early treatment with hydroxychloroquine in people with mild to moderate COVID-19: a systematic review and meta-analysis.

ABSTRACT:

Introduction

No early treatment intervention for COVID-19 has proven effective to date. We systematically reviewed the efficacy of hydroxychloroquine as early treatment for COVID-19.

Material and methods

Randomized controlled trials (RCTs) evaluating hydroxychloroquine for early treatment of COVID-19 were searched in five engines and preprint websites until September 14, 2021. Primary outcomes were hospitalization and all-cause mortality. Secondary outcomes included COVID-19 symptom resolution, viral clearance, and adverse events. Inverse variance random-effects meta-analyses were performed and quality of evidence (QoE) per outcome was assessed with GRADE methods.

Results

Five RCTs (n = 1848) were included. The comparator was placebo in four RCTs and usual care

SUBMITTER: Hernandez AV 

PROVIDER: S-EPMC9266791 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature